Air Filter
LENGE PES Filter Series delivers advanced Polyethersulfone (PES) filtration solutions engineered for high-purity applications in pharmaceutical, biopharmaceutical, food & beverage, and critical process industries. Our PES membranes and filters feature a highly asymmetric gradient structure that provides superior flow rates, high dirt-holding capacity, low protein binding, and excellent chemical compatibility — all while meeting stringent GMP, FDA, USP Class VI, and ASTM standards.
- Highly asymmetric gradient structure for maximum flow and dirt-holding capacity
- Excellent hydrophilicity — wets out instantly for fast startup and reliable integrity testing
- Very low protein binding and adsorption — ensures maximum recovery of active ingredients
- Broad chemical compatibility across full pH range and high-temperature resistance
- FDA-approved materials, USP Class VI compliant, low extractables
- Traceable production under ISO 9001 / ISO 14001 / ISO 45001 systems
- Each cartridge passes 100% integrity testing before shipment
Typical Applications
Sterile filtration of buffers, culture media, vaccines, injectables, and biologics
Final filtration and polishing in pharmaceutical and biopharmaceutical manufacturing
Clarification and microbial reduction in food & beverage, beer, and drinking water
Point-of-use filtration in microelectronics and fine chemicals
Laboratory, R&D, and small-batch processing
FAQs for Better Results
What is PES (Polyethersulfone) and why is it used in filtration?
PES is a hydrophilic microporous membrane material known for its excellent chemical compatibility, high flux, and low protein binding. LENGE PES filters are widely used in pharmaceutical and biopharmaceutical processes because they provide reliable sterile filtration while maximizing recovery of active ingredients.
What are the main types of LENGE PES Filters?
- PES Pleated Filter Cartridge: High-surface-area pleated design for high flow rates and long service life.
- PES Flat Membrane: Asymmetric sheet membrane used for custom assemblies and R&D.
- PES Capsule Filter: Compact, disposable units for small-to-medium volume point-of-use filtration.
What is the bacterial retention performance of 0.22 µm PES filters?
LENGE 0.22 µm PES membranes and cartridges are validated to retain >10⁷ CFU/cm² of Brevundimonas diminuta (ATCC 19146) per ASTM F838-15a method, meeting the highest pharmaceutical sterile filtration requirements.
Are LENGE PES Filters FDA and USP compliant?
Yes. All materials meet FDA 21 CFR requirements, USP Class VI biological reactivity tests (in vivo), and Chinese hygienic safety standards for drinking water equipment. They are manufactured under ISO 9001, ISO 14001, and ISO 45001 systems.
What sterilization methods are compatible with PES filters?
PES filters support multiple methods:
- Steam sterilization (121°C / 30 min, up to 15+ cycles)
- Hot water sterilization (85°C)
- Gamma irradiation and EtO
- Autoclave and SIP (Sterilize-In-Place)
What are the key advantages of the asymmetric structure?
The highly asymmetric gradient pore structure provides:
- High surface porosity on the upstream side for pre-filtration
- Gradually smaller pores toward the downstream side for absolute retention
- High flux, high dirt-holding capacity, low differential pressure, and extended service life
How is the integrity of PES filters verified?
Every pleated cartridge undergoes 100% integrity testing (bubble point and diffusion flow) before shipment. Test limits are directly correlated with bacterial retention results. Flat membranes and capsules are also fully traceable.
What industries commonly use LENGE PES Filters?
Primary applications include pharmaceutical and biopharmaceutical sterile filtration (buffers, vaccines, injectables, culture media), food & beverage clarification, microelectronics ultrapure water, and fine chemical processing.
Can PES filters be customized to my requirements?
Yes. We customize pore size (0.04–0.8 µm), length (2.5"–40"), adapters (222, 226, DOE, etc.), gasket materials (Silicone, EPDM, Viton), and special configurations according to your URS.
How do I select the right PES filter for my process?
Consider:
- Required retention (0.22 µm for sterile filtration, 0.45 µm for bioburden reduction)
- Flow rate and volume
- Chemical compatibility and temperature
- System pressure and housing type
Contact us for a free technical recommendation and validation support.
