VHP Sterilization Chamber for Cleanroom Material Transfer
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Material:
SUS304/316L Stainless Steel
Vaporization Power:
Clean Compressed Air
Sterilization Efficacy:
6-log
Sterilization Time:
<120 min
Cleanliness Class:
Class B
Power Supply:
380V, 50Hz,3kW
The VHP (Vaporized Hydrogen Peroxide) Decontamination Chamber is designed for low-temperature sterilization and surface decontamination of cleanroom transfer items, packaging, medical instruments, production tools, medical devices, and pharmaceutical isolator components.
Using hydrogen peroxide vapor in vapor form, the chamber supports microbial inactivation through oxidation and helps reduce bioburden during sterile material transfer in GMP cleanrooms, pharmaceutical applications, and aseptic processing environments.
It is suitable for temperature-sensitive devices and materials that are not compatible with high-temperature sterilization but can safely withstand vaporized hydrogen peroxide sterilization.
LENGE offers standard VHP sterilization chamber models from 288L to 1440L, with customized chamber dimensions available according to customer URS requirements. Each chamber is designed for controlled hydrogen peroxide sterilization, cleanroom material transfer, and low-temperature surface decontamination in pharmaceutical and medical device environments.
Technical Specifications & Parameters:
Model
Outer Size
Inner Size
Nominal Volume
Cleanliness Class
Sterilization Efficacy
Power
/
W×D×H (mm)
W'×D'×H' (mm)
(L)
/
/
(kW)
LATM288
1200×800×2000
600×800×600
288
Class B
6-log
3
LATM512
1400×800×2200
800×800×800
512
Class B
6-log
3
LATM1000
1600×1060×2100
1000×1000×1000
1000
Class B
6-log
3
LATM1440
1600×1260×2300
1000×1200×1200
1440
Class B
6-log
3
Material
Application
Structure
Sterilization Time
Vaporization Power
Sterilization Efficacy
SUS304/316L Stainless Steel
Pharmaceuticals, Food & Beverage, Electronics
Fully Enclosed
<120 min.
Clean Compressed Air
6-log
Sterilization Media
Maintenance Mode
Inlet Air Purification
Cycling Mode
Validation Document
System Monitoring
Soft System
30% Medical Grade H2O2
Side Access/Up-Down Access
H14
Direct Exhaust
4Q/FAT/SAT
Increase concentration
Display the current step, remaining time and working status of main parts,time setting, system parameter setting, alarm information, online data monitoring,manual and automatic switching, sterilization batch input, validation information,PDF report, formula management
VHP Process and Vaporizer Schematic Diagram
Airflow Diagram
Structure Diagram
The VHP process begins with hydrogen peroxide vapor generation, followed by controlled vapor distribution inside the chamber. During the sterilization process, hydrogen peroxide vapor contacts exposed surfaces and supports microbial inactivation through oxidation.The process requires precise control of vapor concentration, exposure time, relative humidity, temperature range, airflow, and chamber loading conditions to ensure consistent decontamination performance.
Operation Principle:
A01
The built-in VHP generator vaporizes medical-grade hydrogen peroxide and distributes it throughout the chamber in vapor form. As a strong oxidizing agent, hydrogen peroxide vapor contacts exposed surfaces and supports microbial inactivation by disrupting microorganisms through oxidation.
After the decontamination phase, vaporized hydrogen peroxide can break down into water vapor and oxygen when the cycle is properly aerated, helping reduce residual hydrogen peroxide and toxic residue concerns.
Product Description:
A01
The LENGE VHP Sterilization Chamber is designed for sterile material transfer between cleanroom areas with different cleanliness levels. It uses vaporized hydrogen peroxide sterilization to decontaminate the outer surfaces of packaging, production tools, medical instruments, medical devices, and other compatible transfer items before they enter a higher-classified cleanroom area.
The chamber is suitable for GMP-regulated pharmaceutical industry facilities, medical device industry applications, aseptic processing areas, and pharmaceutical isolator-related transfer processes where low-temperature sterilization, material compatibility, and contamination control are essential.
Characteristics & Features:
Rapid Sterilization Cycles
A01
Supports controlled VHP sterilization cycles within 120 minutes, helping improve cleanroom transfer efficiency.
Automated Smart Control
A02
The control system supports automatic operation, parameter monitoring, alarm display, formula management, and batch data recording.
Instant Emergency Stop
A03
Equipped with an emergency stop function to support operator safety during equipment operation.
Low H2O2 Consumption
A04
Optimized vaporization and chamber design help reduce hydrogen peroxide consumption during the sterilization process.
6-log Microbial Reduction
A05
Designed to achieve 6-log microbial reduction against bacteria, fungi, viruses, yeasts, and spores when properly validated.
H14 Air Purification
A06
H14 inlet air purification helps maintain clean airflow and supports contamination control inside the chamber.
Easy Maintenance Access
A07
Side or up-down access options reduce maintenance space requirements and simplify equipment inspection.
URS-Based Custom Design
A01
Chamber size, structure, loading capacity, control system, and documentation can be customized according to the project URS.
VHP Sterilization Chamber
Safeguarding Pharmaceutical Processes and Products
VHP (Vaporized Hydrogen Peroxide) sterilization chambers are a versatile and effective tool for maintaining sterility in cleanroom environments. They utilize hydrogen peroxide vapor to eliminate a broad spectrum of microorganisms, including viruses, bacteria, yeasts, and spores.
VHP Process and Hydrogen Peroxide Sterilization Principle
During the VHP process, medical-grade hydrogen peroxide is vaporized and distributed inside the chamber as a controlled oxidizing agent. The hydrogen peroxide vapor contacts exposed surfaces and supports microbial inactivation by disrupting microorganisms through oxidation.
A validated sterilization process depends on precise control of vapor concentration, exposure time, relative humidity, temperature range, chamber loading, and ambient conditions. After the decontamination phase, vaporized hydrogen peroxide breaks down into water vapor and oxygen, helping reduce residual hydrogen peroxide when the cycle is properly aerated and validated.
Low Temperature Sterilization for Medical Devices
Vaporized hydrogen peroxide sterilization is suitable for many temperature-sensitive devices, medical instruments, packaging materials, and cleanroom transfer components that require low-temperature sterilization.
For the medical device industry and pharmaceutical industry, VHP sterilizers are commonly used when product quality, material compatibility, and controlled surface decontamination are important. Before treatment, materials should be checked for compatibility with hydrogen peroxide vapor.
Applications in Pharmaceutical Industry and Aseptic Processing
LENGE VHP Sterilization Chamber can be used in pharmaceutical applications, aseptic processing areas, GMP cleanrooms, laboratories, healthcare facilities, and cleanroom material transfer chambers.
It supports the surface decontamination of packaging, medical instruments, cleanroom tools, medical devices, production components, and pharmaceutical isolator-related transfer items. For drug products, pre-filled syringes, and sensitive components, VHP is more suitable for external packaging, compatible surfaces, and transfer-related decontamination rather than direct treatment of liquids.
Material Compatibility and Process Control
Successful vaporized hydrogen peroxide sterilization depends on material compatibility, chamber loading, exposure time, vapor concentration, relative humidity, and temperature range. Organic debris should be removed before treatment to support effective microbial inactivation.
VHP is not suitable for liquids and may have limited penetration capability in long, narrow lumens or certain absorbent materials. For this reason, process development and validation are important before routine sterilizing operations.
Real-World Success Stories in Pharmaceutical Manufacturing
VHP Sterilization Chamber Case Diagram
001/002
VHP Sterilization Chamber Case Diagram
002/002
FAQs
01
What is vaporized hydrogen peroxide sterilization?
Vaporized hydrogen peroxide sterilization is a low temperature sterilization method that uses hydrogen peroxide vapor in vapor form to treat exposed surfaces. As an oxidizing agent, it supports microbial inactivation through oxidation. It is commonly used for cleanroom decontamination, medical device sterilization, pharmaceutical applications, and VHP Sterilization Chamber systems.
02
How does the VHP process work inside the chamber?
The VHP process is an automated, multi-stage sterilization process designed for precise control. A typical cycle includes:
Dehumidification
Conditioning
Decontamination
Aeration
The effectiveness depends on vapor concentrations, exposure time, relative humidity, temperature range, and ambient conditions.
03
Is VHP sterilization suitable for medical devices and medical instruments?
Yes. VHP sterilization is used for many medical devices, medical instruments, and temperature sensitive devices that may not tolerate steam sterilization, moist heat, or dry heat. It is widely used in the medical device industry where low temperature sterilization and material compatibility are important. Before routine sterilizing, each material should be checked for compatibility with hydrogen peroxide.
04
How is hydrogen peroxide sterilization different from ethylene oxide or steam sterilization?
Hydrogen peroxide sterilization is a low temperature sterilization modality, while steam sterilization relies on moist heat and ethylene oxide uses gas. VHP breaks down into water vapor and oxygen after sterilization, helping reduce toxic residue concerns. Method
Better suited for
Main consideration
VHP sterilization
Temperature sensitive devices, cleanroom items
Surface exposure and material compatibility
Steam sterilization
Heat-resistant materials
May affect product quality
Ethylene oxide
Certain complex devices
Residue and aeration control
05
Does VHP sterilization leave toxic residue?
When properly aerated and validated, VHP sterilization can leave no toxic residues behind because hydrogen peroxide vapor breaks down into water vapor and oxygen. Residual hydrogen peroxide should still be monitored as part of the sterilization process. High concentration hydrogen peroxide vapor can be dangerous to humans, so chamber sealing, exhaust, and process control are essential.
06
Can VHP sterilization achieve a 6-log microbial reduction?
Yes. A validated VHP sterilization cycle can achieve a 6-log reduction of microorganisms and support effective microbial inactivation. VHP is effective against a broad spectrum of microorganisms when key process factors are controlled:
Hydrogen peroxide concentration
Exposure time
Relative humidity
Temperature
Chamber loading
Biological indicators can be used to verify cycle effectiveness in aseptic processing and pharmaceutical industry applications.
07
Can VHP sterilization be used for liquids, pre filled syringes, or drug products?
VHP sterilization is mainly a surface sterilant and is not suitable for direct sterilization of liquids. For pre filled syringes and drug products, it is more suitable for:
External packaging
Compatible surfaces
Transfer components
Isolator-related transfer items
Vaporized hydrogen peroxide also has limited penetration capability in long, narrow lumens and may be incompatible with cellulosic materials.
08
Where are VHP sterilization chambers used in aseptic processing?
VHP sterilization chambers are used in aseptic processing, pharmaceutical industry facilities, healthcare facilities, laboratories, RABS, and pharmaceutical isolators. They help reduce bioburden on packaging, tools, devices, and transfer materials before entering higher classified cleanroom areas. For controlled cleanroom transfer, they can work with material transfer chambers, HEPA filters, and other cleanroom systems.
